Castleman’s disease (CD) is a lymphoproliferative lesion that primarily occurs in the mediastinal region followed by the cervical lymph nodes. CD in the facial region is rare. In the present article, we report a rare case of CD arising in the buccal region and review the literature. A 39-year-old woman with a painless mass arising in the right buccal region was referred to our division. Her facial appearance was symmetrical. A relatively hard, well-defined and mobile mass was palpable in the right side of the cheek. Computed tomography showed an oval-shaped, homogeneous radiopaque mass measuring approximately 10 mm in diameter. Magnetic resonance imaging of the mass revealed low signal intensity on T1-weighted images, slightly higher signal intensity than muscle on T2-weighted images, and moderate signal intensity on STIR images, similar to the signal intensity of the palatal tonsils. We clinically diagnosed a benign mesenchymal tumor. Intraoral surgery was performed with the patient under general anesthesia to excise the mass through the buccinator muscle. The histopathological diagnosis was a hyaline-vascular type of CD. No lymphoproliferative lesions were detected on whole-body 18 fluoro-2-deoxyglucose positron emission tomography postoperatively. The postoperative course was uneventful, with no evidence of recurrence as of 2 years 5 months after surgery.
