慢性皮膚粘膜カンジダ感染の患者に下顎歯肉癌と食道癌を認めた1例

抄録

A 44-year-old woman had been monitored by her previous doctor for the progression of oral candidiasis and hyperkeratosis in the molar region of the left mandibular gingiva for 4 years. Tissue biopsy of an exophytic growth revealed squamous cell carcinoma, and she presented to our department for radical treatment. Furthermore, her son had a STAT1 gene abnormality, which is responsible for chronic mucocutaneous candidiasis (CMC). The patient had the same abnormality and was given a diagnosis of CMC. At the first visit to our department, the exophytic tumor had progressed to 25 × 15 mm with possible lymph node metastasis in the left submandibular region. Therefore, gingival carcinoma (cT2N1M0) was diagnosed. Screening of the upper digestive tract revealed thoracoesophageal carcinoma (cT1N0M0). Therefore, radical surgery for these carcinomas was performed on the same day after discussions with gastroenterological surgeons.

　Postoperatively, the patient’s condition was good, and the gingiva and esophageal carcinomas are currently under control for 2 years. However, the patient is being carefully monitored owing to the presence of CMC, which acts as a carcinogen.