A case of multiple sialolithiasis in the submandibular gland and duct is reported. A 71-year-old man was referred to the Department of Oral and Maxillofacial Surgery in our hospital. He had no symptoms in the right submandibular region, but panoramic radiography and computed tomography showed multiple calculi in the right submandibular gland and duct. The patient underwent excision of the right submandibular gland with Wharton’s duct including multiple stones. A total of 332 sialoliths were detected, and the submandibular gland tissues were normal histopathologically. The postoperative period was uneventful, and the patient recovered without any complications. This is a rare case with the largest number of sialoliths ever reported.
