抄録
Cefbuperazone distribution in oral tissue and inflamed mouth floor of mice was examined by agar well method.
After abdominal administration of Cefbuperazone 200 μg/g in mice, tissue concentration of mouth floor and submandibular gland reached a peak in 5 minutes, that of mandibular bone, tongue, masseter, and serum in 10 minutes, and that of femur in 30 minutes. The tissues in order of concentration were the serum, mouth floor, femur, submandibular gland, tongue, masseter and mandibular bone.
After abdominal administration of Cefbuperazone 200 μg/g in mice of which mouth floor had been inflamed, the concentration of inflamed mouth floor reached a peak in 10 minutes. As compared with normal mouth floor, Cefbuperazone was highly distributed in inflamed mouth floors.
