Oral florid papillomatosisの1例

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In 1960, Rock et al reported three cases of papilloma showing u florid type of multiple fusion in the oral cavity and larynx diagnosed as florid papillomatosis. Although no malignant finding has been histologically observed in this disease, it is extremely intractable and its radical treatment is very diffcult in the clinical practice.
We recently experienced on extended oral florid papillomatosis from the upper and lower lips to the right and left buccal mucosa in 59 year-old man. Clinically, a malignant tumor was suspected, however, the histological finding showed no malignant feature such as deep infiltration of epithelial cells and ruptured basement membrane though the epithelial hyperplasia with marked acanthosis was observed.
Chemotherapy resulted in some therapeutic effect but failed to give a complete resolution. The discrimination of this disease from verrucous carcinoma could not be made from the pathological standpoint. However, a diagnosis of oral florid papillomatosis seemed more suitable to this case from the clinical standpoint for understanding the state of disease more accurately.