下顎骨と下腿骨に特徴的変化を呈した小児急性リンパ性白血病の症例

抄録

We describe a unique case of 12-years-old girl who was referred to this clinic because of gingival hypertrophy, loosened teeth, and painful leg.
A panoramic dental radiograph of the patient revealed a number of abnormal features including cancellous bone destruction with diffuse cloudiness especially noticeable in the premolar and molar regions, loss of alveolar crestal bone, disappearance or thinning of lamina dura of the premolar and molars, disappearance of the mandibular nerve canals, thickening of periodontal membrane space, and enlargement of the both mental foramina.
After examinations of the peripheral blood and the bone marrow, the case was diagnosed to be B-cell acute lymphocytic leukemia.
Although antileukemic chemotherapy was undertaken at the pediatrics, she died on the 66th hospital day because of interstitial pneumonia.
Thus, we suggest that panoramic radiography of the jaws could provide an important clue for diagnosis of some kind of leukemia.