This report describes a clinical application of fibrin adhesive consisted of high concentrated human fibrinogen, thrombin and blood coagulation factor XIII (fibrin stabilizing factor). Fibrin adhesive is a biological substance which is completely absorbed from bio-tissues dissimilar to conventionally used synthetic adhesives. In addition, this agent has an excellent adhesive property, firm elasticity and superior tissue affinity.
We applied this method in 37 cases undergone various operations in the oral surgery, including 1) adhesive fixation of isolated skin flaps or frozen cerebral dura mater (Lyodura®) against soft tissue defects in the cheek and tongue, 2) adhesive fixation of mucoperiosteal flaps against bare bone, 3) adhesive fixation of isolated skin flaps or lyophilized porcine skin flaps against bare bone and 4) application in palatoplasty, that is, adhesive fixation of platal flaps and lyophilized porcine skin flaps against palatal bone. The application of this agent was revealed from this study to be superior in its favorable tissue adhesive property, local hemostasis and wound healing effect. We also described indications of this method in the oral surgery.
