Forty-six patients with oral squamous cell carcinoma were reviewed clinicopathologically. A histological classification was performed on the initial biopsies prior to treatment, and the correlation between histological factors and prognosis was investigated.
Four different histological factors (Differentiation, Nuclear polymorphism, Mitoses and Cellular response) were evaluated and scored on a three-point scale. Total points of each case in this series were distributed from 4 to 10 points and divided into three classes: low grade malignancy (4-6 points), middle grade (7-9 points) and high grade (10-12 points).
The high grade malignancy cases indicated poor prognoses compared with those of low grade. Differentiation of tumor cell may be a significant factor in determining histological grade of malignancy has been suggested.
