For clinical application of ASPC in the oral field, a pharmacokinctic analysis was performed for ASPC concentration in the oral tissue, and the following results were obtained:
1) ASPC with a dose of 1 g was administered to 38 patients by one shot intravenous injection. Serum ASPC concentration was 46.7 μ g/ml 30 min and 12.2 μ g/ml 120 min after injection. The half life of ASPC in serum was thus estimated to be 2.2 hr.
2) Concentration of ASPC in gum and cyst wall ranged from 30 to 35% of the serum level at the highest. Peak concentration in bone was 14.9% of the serum value.
3) The AUC value and the duration time gave satisfactory results and we found that the ASPC distribution to oral tissues was good.
