For the study of the clinical application of Cefbuperazone (CBPZ, keiperazone) in the oral field, fundamental studies on CBPZ were carried out and the following results were obtained.
1) In vitro antibiotic activity of CBPZ agaist 57 clinical isolated organisms from oral infection cases were examined. The peak of the minimum inhibitory concentraion was 12.5 μg/ml.
2) Doses of 1 g CBPZ were administrered to 45 patients by one shot intravenous injection, and pharmacokinate analysis was performed. The half life of CBPZ in serum was thus estimated to be 114 minutes.
3) The hightest concentratins of CBPZ were 32.1 μg/mlin the gum and 31.8 μg/ml in the cyst wall. These concentraions were noted to show good distribution.
The above results suggested the usefulness of CBPZ for the treatment of any oral surgery infections.
