抄録
Serum sialic acid in patients with acute oral bacterial infections and healthy parsons was measured by enzymatic method. Significant raised levels of serum sialic acid were found in patients with acute infections as compared with healthy persons. Serum levels of sialic acid corresponded with the clinical condition of infections diseases and recovered normally with clinical improvement. Serum concentrations of sialic acid were well correlated with those of C-reactive protein and numbers of white blood cells. In addition, serum sialic acid significantly increased postoperatively.
As human serum does not contain free sialic acid and sialic acid almost binds to glycoprotein such as C-reactive protein, acid glycoprotein, and so on, these results suggest that raised levels of serum sialic acid may be caused by the increase of acute phase proteins. Therefore, measurement of serum sialic acid is thought to be useful as a marker which reflects the clinical condition of infections diseases rather than infections themselves.
