アスピリン投与による創傷治癒遅延について

抄録

Measurements of the blood flow kinetics in healed wounds which had been sutured by nylon thread were carried out in the group of mice receiving aspirin (300mg/kg) and the control group, using the laser doppler flowmeter (LDF) and the results were histopathologically compared. The following interesting results were obtained.
1) Blood flow kinetics in wound areas in the group sutured by nylon thread increased from the 1st postoperative day till the 14th day.
2) When aspirin was administered at doses of 300mg/kg, the blood flow decreased from the 1st postoperative day till the 4th day and then gradually returned to normal level. But there was a significant difference between the group receiving aspirin and the control group.
3) On histopathological studies wound healing process was normal in the group sutured by nylon thread. In aspirin administered group, however, gaping of the wound was seen on the 3rd postoperative day and the wound showed healing tendency from the 5th postoperative day and the wound showed healing tendency from the 5th postoperative day. Therefore, wound healing process was more delayed than that in the control group.
These results indicate that the measurements of blood flow using LDF can reflect the peripheral blood flow kinetics and show a good coincidence with the change in histopathological findings. Therefore, LDF can sensitively measure a delicate change in the tissue blood flow. In addition the administration of aspirin was found to delay the healing process in incised wound of mouse-skin.
Consequently, it is necessary to determine the time to take out the stiches in consideration of the fact that the administration of non-steroidal antiinflamatric analgesics may delay wound healing process, although extractin of the stiches has been generally carried out on the 7th postoperative day.