In direct relation to the extension of the average span of human life, the incidence of the double cancer has been increased, though still uncommon in the oral region.
The case of a 57 year old female, in whom an adenocarcinoma of the sigmoid colon was followed by a squamous cell carcinoma of the left mandible, is reported herein. The onset of the latter occurred forty two months after a successful excision of the earlier carcinoma.
Based on retrospective survey of 82 cases of oral-related double cancer reported in past Japanese literature, the results are summarized as follows:
1) Sex: Male/Female=2.9/1
2) Age: 89.1% of cases occurred over the fifth decade of life.
3) Interval of the cancers. Majority of the cases (83.1%) had the second cancer within 5 years.
4) Gastrointestine proved to be the most highly affected system (56.9%) in oral-related double cancers.
5) In regard to the histopathological typing of both cancers, squamous cell carcinoma and adenocarcinoma were the two major constituent types?
