Classification and treatment of oral melanoma have not been established. We reported the heterogeneity of oral melanoma consisting of acral lentiginous melanoma (ALM) and nodular melanoma (NM) in Part I. In this Part, the clinical courses of our nine and 47 reviewed cases of oral melanoma were analyzed retrospectively.
Most of the reviewed cases had poor prognosis because of distant metastasis as well as local recurrence. We have treated oral melanoma by 1) surgical excision of the primary tumor, 2) neck dissection in Stage II case, 3) adjuvant immunochemotherapy with DTIC, ACNU, VCR, and OK-432. The prognosis of our cases are fairly good in contrast to those of the reviewed cases.
