顎骨内嚢胞形成性疾患におけるFlomoxef Sodium (FMOX) の組織移行性に関する臨床的検討

抄録

Flomoxef sodium (FMOX), a new oxacephem antibiotic, was preoperatively administrated by i.v. drip infusion in patients with cyst formation in the jaw. Then the concentrations of FMOX in serum, bone, cyst wall or cyst-like structure in the jaws, and its content, all collected during operation, were examined. The results were as follows.
1. Mean concentrations of FMOX in serum, bone, cyst wall or cyst-like structure, and its content at a dose of 1g were 17.66, 3.03, 8.88, and 3.45 μg/ml.g, respectively. At a dose of 2g, those were 31.27, 6.46, 15.74 and 9.12 μg/ml.g, respectively. Mean concentrations at a dose of 2g were almost twice as high as those at a dose of 1g.
2. Mean ratios of the antibiotic transferred into the bone, cyst wall or cyst-like structure, and its content to that in serum, were 18.39, 52.64, and 24.31%, respectively in the patients recieved 1g FMOX injection. The corresponding ratios were 20.29, 51.87, and 29.26% in those recieved 2g FMOX injection. These patients in the two dosing groups showed almost the same degree of transfer.
3. When the degree of FMOX transfer into the cystic content was examined according to the histopathological type, it was highest in the radicular cyst, being about 3-to 4 fold these of other histological types.