A case of peripheral T-cell malignant lymphoma (clinical stage IE) arising from the oral cavity analysed histopathologically, immunohistochemically and molecularbiologically is reported.
A 77-year-old man visited our hospital with complaints of swelling and spontaneous pain of the right molar region of the mandible. Physical examination revealed a swelling with ulcer formation on the right mandibular molar alveolar gingiva. A biopsy from the gingiva showed malignant lymphoma (Malignant lymphoma, large cell, immunoblastic, polymorphous: WF classification, Diffuse lymphoma, pleomorphic type: LSG classification).
As a result of immunohistochemical examination, this tumor was CD 25, CD 71, HLA-DR antigen expressed helper/inducer T-cell lymphoma. Molccularbiological examination with polymerase chain reaction (PCR) and southern blotting method indicated that this tumor did not involve human T-cell lukemia/lymphoma virus type-1 (HTLV-1) genorne. Although the tumor disappeared after local irradiation, the patient died of pneumonia in 11th month following fist visit.
