Recently, cyclosporin-A (Cy-A) induced gingival hyperplasia has been reported. We examined the oral condition of 8 patients with kidney transplants who were administered Cy-A at Tottori Prefectural Central Hospital, and found gingival hyperplasia in 3 patients. We studied the total dose and duration of Cy-A treatment in the 8 patients. In the group with gingival hyperplasia, the mean total dose given until gingival hyperplasia appeared was 2, 433.2 mg/kg, and the mean period until gingival hyperplasia appeared was 744.3 days. In the group without gingival hyperplasia, the mean total dose was 5, 462.7 mg/kg, and the mean period of treatment was 1, 278.6 days at the time of the study. Oral hygiene was evaluated by the Oral Hygiene Index-Simplified (OHI-S). In the group with gingival hyperplasia, the mean OHI-S score was 3.66, while in the group without gingival hyperplasia, the mean OHI-S score was 1.65. No correlation was found between gingival hyperplasia and either the total dose or the duration of Cy-A treatment. A significant correlation was found between gingival hyperplasia and oral hygiene.
