抄録
This study reviewed 9 patients (2.8%) with multiple primary oral cancer in the maxillofacial region who were treated at the Department of Oral and Maxillofacial Surgery of Kanagawa Dental College from 1970 to 1992. The patients ranged from 36 to 73 years of age (mean 56 years). There were 3 males and 6 females. Primary cancers (all squamous cell carcinoma) were found in the mandibular and maxillary gingiva in 3 cases, right and left buccal mucosa in 1 case, right and left maxillary sinus in 1 case, tongue and buccal mucosa in 1 case, maxillary gingiva and buccal mucosa in 1 case, mandibular gingiva and buccal mucosa in 1 case, and in the mandibular gingiva and maxillary sinus in 1 case. Background factors included Plummer-Vinson syndrome in 1 case, and multiple leukoplakia in 3 cases. The interval between the appearance of primary and secondary carcinomas ranged from 6 months to 8 years and 5 months ; the average interval was 3 years and 11 months. TNM classification of the primary cancer was T1 in 1 case, T2 in 5 cases, T3 in 3 cases, NO in 4 cases, Ni in 5 cases, and MO in every case. TNM classification of the secondary cancer was T1 in 3 cases, T2 in 3 cases, T3 in 3 cases, NO in 6 cases, N1 in 3 cases, and MO in every cases. TNM classification of the tertiary cancer was T1NOMO in 2 cases. In primary carcinomas, 5 cases were treated with chemotherapy, radiation and surgery, 2 cases with chemotherapy and radiation, and 2 cases with surgery alone. In secondary lesions, 3 cases were treated with chemotherapy, radiation and surgery, 2 cases with radiation and surgery, 3 cases with surgery alone, and 1 case with chemotherapy and radiation. In tertiary lesions, 2 cases were treated with surgery alone. During an observation period ranging from 2 to 14 years. 5 patients are still alive and 4 have died of cancer.
