口腔扁平上皮癌におけるFGF-1およびFGF-2の発現

抄録

In this study, we examined the expression of fibroblast growth factor-1 (FGF 1) and FGF-2 in oral squamous cell carcinomas (SCC) by immunohistochemical technique using specific monoclonal antibodies. In vitro growing oral SCC cells expressed both FGF-1 and FGF-2 in their cytoplasms and nuclei, but no staining was observed when the cells were confluent. In vivo, the expression of FGF-1 and FGF-2 in 13 oral SCC cases was examined. Compared to normal oral epithelium, SCC showed a high frequency and intense staining of both FGF-1 and FGF-2. These results indicate that SCC cells express high levels of endogenous FGFs and suggest that these growth factors may contribute to cancer cell growth as part of an autocrine mechanism.