A case of verrucous carcinoma of the oral floor which had an excellent response to tegafur alone is reported.
A 76-year-old woman complained of a swelling in the oral floor of 8 months' duration. Oral examination revealed an approximately elliptical tumor that measured 45×20×15mm and extended bilaterally from the oral floor to the alveolar mucosa. Regional lymph nodes were not clinically involved, and no distant metastasis was evident. She was orally administered 600mg per day of tegafur before operation. The tumor was reduced to about half of its primary size 10 days after the start of tegafur treatment. Two months later, no remaining verrucous carcinoma was observed on histologic examination.
There were no noteworthy side effects. There is no evidence of recurrence or metastatic disease as of 28 months after treatment.
