A case of a central giant cell granuloma arising bilaterally in the mandible of a 19-year-old woman is presented. The patient complained of swelling of the gingiva around the molars of the left mandible. Radiographic examination revealed that the lesion was located in the anterior margin of the ramus of the mandible bilaterally and the apical area between the second premolar and the first molar of the right side of the mandible. The lesion was excised completely under general anesthesia and was diagnosed as a giant cell granuloma on both clinical and histopathological examinations. There has been no evidence of recurrence as of more than one year after surgery. Twenty-seven cases, including our own, have been reported in Japan since 1973. Analysis of these cases revealed that central giant cell granuloma occurs most freguently in teenage girls and that the ramus of the mandible is most commonly involved, Intensive follow-up is required because 19% of these cases have recurred.
