Neurilemmoma is a benign tumor derived from abnormal growth of Schwann cells. We report a case of a large neurilemmoma in the oral cavity. A 60-year-old man was referred to our department because of a tumor in the right side of the mouth floor. Clinically, the tongue was deviated to the left by the tumor, and magnetic resonance imaging showed a large oval mass. The clinical diagnosis was a benign tumor. The tumor was excised intraorally under general anesthesia. The excised specimen had a yellowbrownish surface, measured 65×42×35mm, and weighed 49 grams. The histopathological diagnosis was a neurilemmoma. The postoperative course of the patient has been good for 3 months.
