Cheilitis granulomatosa (CG) is a chronic inflammatory disorder of unknown etiology. Various types of symptomatic therapy have been used to manage CG, with varying success. Recently, CG has been considered part of a new concept of disease referred to as “orofacial granulomatosis”. We report on a 40-year-old woman with persistent CG of the upper and lower lips that was successfully managed by local injection of dexamethasone. Treatment consisted of local injection of 4 mg dexamethasone diluted with lidocaine hydrochloride, administered at intervals of 1 to 4 weeks over the course of 7 months. After 5 months of treatment, both the upper and lower lips of the patient appeared normal. On follow-up at 1 year, the patient's lips remained normal in shape and contour.
