Primary malignant melanoma of the oral region is relatively rare. The prognosis of malignant melanoma in the oral region is poor. We report a case of malignant melanoma treated successfully with chemotherapy, local administration of high-dose interferon-β, and surgery. A 40-year-old man was referred to our department because of swelling of the upper alveolar gum. On67Ga-citrate scintigraphic examination, abnormal accumulation of RI was observed in both the maxillary region and the left upper neck region. Signs of metastasis to the regional lymph nodes were evident on computed tomograhic examination.The patient was treated by combination therapy consisting of surgery, chemotherapy, and immunotherapy. Before operation, one cycle of chemotherapy with CDDP, DTIC, and local administration of high-dose interferon-βwas carried out. Postoperatively, three cycles of DAV chemotherapy were administered. In the 7 years after operation, neither local recurrence nor distant metastasis has been clinically detected. However, it is very important to continue follow-up because malignant melanoma has a high recurrence rate.
