歯科用キシロカイン^®中に含まれるピロ亜硫酸ナトリウムによるアナフィラキシーショックの1例

抄録

We report a rare case of anaphylactic shock during tooth extraction. The patient had atopic dermatitis for about 20 years. Although the serine IgE level was high, the results of drug lymphocyte stimulation tests (DLST) against all ingredients in the local anesthetics were negative.
However, when we performed skin-tests against sodium metabisulfite and para-oxy benzoic acid methyl, small amounts of which were contained in the local anesthetics, sodium metabisulfite induced an allergic reaction.
We conclude that this was a rare case of anaphylaxis caused by sodium metabisulfite in a patient with atopic dermatitis.
We should be especially cautious when we use local anesthetics in patients with atopic dermatitis.