Malignant schwannoma is a malignancy of a peripheral nerve. This tumor rarely occurs in the oral region.
We report a case of malignant schwannoma arising in the mandible of a 60-year-old man. The tumor and regional mandibular bone were excised. On microscopic examination, the tumor was mainly composed of short spindle-shaped cells, arranged in dense, interlacing fascicles or whorls. Immunohistochemically, the tumor cells were positive for S-100 protein and neuron-specific enolase. Ultrastructurally, the tumor cells contained fibrous long-spacing collagen. The relevant literature is discussed.
