We present two cases of syphilitic cervical lymphadenitis with a hard chancre at the angle of the mouth.Case 1: The patient was a 46-year-old man. A medical examination revealed an indurated ulcer at the left angle ofthe mouth, with lymph node swelling in the left side of the neck. The swollen cervical lymph nodes were immobileand elastic hard on palpation, with tenderness. CT images revealed multiple swollen lymph nodes around the leftsubmandibular gland and in both the deep cervical and the left supraclavicular lymph nodes. Serological examinationrevealed elevated RPR (3+), TPHA test (2+), and FTA-ABS test (+) values.Cervical lymphadenitis dueto primary syphilis was diagnosed. Case 2: The patient was a 33-year-old man.A medical examination revealed anindurated ulcer at the right angle of the mouth and swollen lymph nodes in the right side of the neck. CT imagesshowed multiple swollen lymph nodes in the anterior portion of the right submandibular gland and in both thedeep cervical and submental regions. Serological examinations revealed elevated TPHA test (2+) and FTA-ABStest (+) values. Syphilitic lymphadenitis was diagnosed.
