Abstract
We successfully performed granulocyte transfusions for an 11-year-old boy with acute myeloblastic leukemia who developed cervical phlegmone with profound neutropenia after chemotherapy. Initial induction therapy failed and salvage therapy was then performed. Despite the administration of appropriate antibacterial agents, he developed right cervical phlegmone caused by Pseudomonas aeruginosa. After obtaining an informed consent for G-CSF administration and granulocyte donation from his father, who was ABO compatible, we collected, respectively, 1.2 × 1010 and 2.2 × 1010 granulocytes following the second and third doses of G-CSF. Granulocyte concentrates were infused with 15 Gy immediately for 2 hr after irradiation and yielded complete recovery. No adverse reactions were observed. Our findings suggest that granulocyte transfusions are useful for critically ill patients with severe neutropenia.
