Successful Treatment with Recombinant Human Granulocyte Colony Stimulating Factor (rhG-CSF) in Stevens-Johnson Syndrome Associated with Agranulocytosis-

Abstract

A 6-year-old boy with Stevens-Johnson syndrome was seriously ill with infection due to agranulocytosis on the 5th day of the disease. rhG-CSF (Cyugai rG·CSF) alone was given subcutaneously at the doses of 2μg/kg/day from the 9th day of the disease. No corticosteroids were administered. Granulocytes increased up to 7, 000/μl on the 13th day of the disease and his general condition was markedly improved. The serum G-CSF level was detected to be 8, 445 pg/ml during an agranulocytic period, which gradually decreased after the normal range of granulocytes was obtained. This case report indicates that treatment with rhG-CSF is beneficial for patients with Stevens-Johnson syndrome associated with agranulocytosis.