We continuously injected 9 antimicrobial drugs (Viccillin®, Pentcillin®, Unasyn-S®, Pansporin®, Cefmetazon®, Rocephin®, Sulperazon®, Flumarin®, Fosmicin-S®) intravenously into the rabbit pinna vein. For the dissolution of the drugs, we used a 0.9% isotonic sodium chloride as the physiological saline solution in a volume of either 50 mL or 100 mL. We conducted pathological examinations consisting of number of white blood cells (WBC), production of the C-reactive protein (CRP) and vascular lesion characteristics of the pinna vein as a means of determining the appearance of adverse reactions. There was no significant change in these pathological indications between before and after administration of the solutions, and there were no histological changes. This suggested that a change in volume of physiological saline used for dissolution from the usual 100 mL to 50 mL causes no problems in solubility.
