一般論文
市販のインスリン注入器と専用注射針を用いた注入抵抗の比較と患者への手技指導上の留意点
2006 年 32 巻 8 号 p. 723-728
詳細
2006 年 32 巻 8 号 p. 723-728
Owing to the large infusion resistance of insulin injectors, instruction on self injection is sometimes difficult for diabetes mellitus patients who are elderly or have disability in their fingers. This is considered to be due to the structure of the injector and the thin injection needle used. In this regard, 4 types of injection needles were attached to each of 8 types of commercialized injectors and the changes in the infusion resistance were determined for the purpose of investigating the important points in instructing patients. As for the method, the infusion resistance after infusion of 20 units of insulin in 10 seconds was determined using an autograph, and the infusion resistance curve, maximum infusion resistance and area under infusion resistance curve (AUIRC) were obtained in order to investigate the characteristics of each injector and the difference in infusion resistance in combination with the injection needles. The results showed that there were differences in the infusion resistance curve, maximum infusion resistance and AUIRC among the different types of injector. Infusion curves were classified into a “regular type” that has a regular amplitude and an “irregular type” that does not have a regular amplitude. For the former, the amplitude was large in some and small in others and for the latter, a marked increase in infusion resistance was observed. The InnoLet® and HumaPen® Luxura injectors had a smaller maximum infusion resistance than the AUIRC OptiPen®Pro 1 and OptiClik® injectors.
In consideration of cautions that have to be observed in instructing patients on the injection technique, InnoLet was thought to be the most suitable for elderly patients and those having decreased grip strength due to hemiplegia, etc., since its infusion resistance was the smallest and it does not require to be assembled (prefilled preparation). In the case of the irregular types Humacart®Kit and OptiPen®Pro 1, and OptiClik®, it is important to check whether the patient can keep pushing the infusion button until the injection procedure has been completed.
