抄録
The new formulation of clarithromycin dry syrup (CAMD),whose particles are coated with aminoalkyl methacrylate copolymer RS,came onto the Japanese market in June 2006.The purpose of this study was to compare the bitterness suppression of the new formulation of CAMD with its old formulation.In order to do this,we had the parents of pediatric patients (0 to 7 years old) fill out a questionnaire regarding their children’s compliance.We found that the bitterness of the macrolide antibiotic was a cause of non-compliance among children and that the bitterness of the new CAMD formulation was suppressed even when it was made into a suspension in an acidic beverage (pH 3.5).This is because the dissolution rate of clarithromycin in the new CAMD formulation is suppressed to a greater extent than that in the old CAMD formulation.
