医療薬学
Online ISSN : 1882-1499
Print ISSN : 1346-342X
ISSN-L : 1346-342X
一般論文
タクロリムス血中濃度測定機器の比較検討
北原 隆志中川 博雄清水 千恵子浅井 瑶奈兒玉 幸修濱本 知之藤 秀人佐々木 均
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2009 年 35 巻 7 号 p. 453-457

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IMxTM,an instrument using the Microparticle Enzyme Immunoassay,has been widely used in monitoring tacrolimus (TAC) blood levels. However,recently,ARCHITECT® ,an instrument using the Chemiluminescent Immunoassay,and Dimension® ,which uses the Affinity Column Mediated Immune Assay,have started to be used for this purpose in the clinical setting. Compared with IMxTM, ARCHITECT® has higher measurement accuracy and the measurement procedure is simpler with Dimension®. In this study,we evaluated the 3 instruments as regards determining TAC concentrations. ARCHITECT® was more accurate than IMxTM and Dimension® in measuring low TAC concentrations (5 ng/mL or less) and reduced the variation in measurements among people making them.However,as manual pretreatment is not required before the measurement procedure with Dimension® ,it had the shortest measurement time (24 minutes) among the instruments.

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© 2009 日本医療薬学会
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