2009 年 35 巻 7 号 p. 453-457
IMxTM,an instrument using the Microparticle Enzyme Immunoassay,has been widely used in monitoring tacrolimus (TAC) blood levels. However,recently,ARCHITECT® ,an instrument using the Chemiluminescent Immunoassay,and Dimension® ,which uses the Affinity Column Mediated Immune Assay,have started to be used for this purpose in the clinical setting. Compared with IMxTM, ARCHITECT® has higher measurement accuracy and the measurement procedure is simpler with Dimension®. In this study,we evaluated the 3 instruments as regards determining TAC concentrations. ARCHITECT® was more accurate than IMxTM and Dimension® in measuring low TAC concentrations (5 ng/mL or less) and reduced the variation in measurements among people making them.However,as manual pretreatment is not required before the measurement procedure with Dimension® ,it had the shortest measurement time (24 minutes) among the instruments.