In response to the medical needs for human immunoglobulin, intravenous formulations of human immunoglobulin with various modifications have been developed after many years of research. However, few studies have been conducted for the detailed comparison of the characteristics of intravenous human immunoglobulin (IVIG) preparations. In the present study, physicochemical properties of six (6) IVIG preparations that are commercially available in Japan were investigated in detail. Consequently, it was found that there are differences among these IVIG preparations in terms of IgA contents, viscosity and Factor XI activities. It is necessary to promote the appropriate use of IVIG preparations in medical practice giving careful consideration to the characteristics of each IVIG preparation.