抄録
Owing to the popularity of health food consumption for improving health or beauty, the health food market has been steadily growing in Japan in recent years. Accordingly, harmful interactions between health foods and prescription drugs are predicted to increase because patients who are administered prescription drugs are reported to consume more health foods. We aimed to determine the status of health food consumption in patients and consumers visiting pharmacies, and we investigated whether health foods inhibit cytochrome P450 2D6 (CYP2D6) activity in vitro. We conducted a questionnaire survey in pharmacies on the current use of health foods. We received 1,041 responses, and of these respondents, 69.3% consumed health foods, over-the-counter drugs, or foods with health claims, and the use of 249 health foods was confirmed. In addition, a CYP2D6-expressing cell model was constructed using the human hepatoma cell line and the CYP2D6-expressing adenovirus; this model was used to assess the in vitro inhibitory effects of 172 of the 249 products, which were available at drug stores or on the Internet, on CYP2D6 activity by using high performance liquid chromatography and liquid chromatography/tandem mass spectrometry. CYP2D6 activity was inhibited by 6 products, including turmeric-, a component having diet effect-, garlic-, and collagen-containing health foods. This study revealed the status of health food utilization and identified the health foods that are currently consumed. Furthermore, we found that 6 products found in these health foods have the potential to inhibit CYP2D6 activity. Our results may provide helpful information to avoid health food-drug interactions during medication use.
