ミニレビュー
大学から発信するEvidence-based hospital formulation（EBHF）
2016 年 42 巻 7 号 p. 492-498
詳細
2016 年 42 巻 7 号 p. 492-498
A “hospital formulation” is medicine prepared by hospital pharmacists when doctors cannot provide the medical therapy most suitable for a patient using commercial pharmaceuticals. However, as the responsibilities of pharmacists are increasing, the ability to provide hospital formulations is decreasing. The development of evidence-based hospital formulations is thus limited. Irsogladine maleate (IM) is a drug with gastric mucosa-protective properties. IM increases intracellular cyclic adenosine monophosphate levels in the gastric mucosa and activates communication between cells. Oral administration of IM has been reported to reduce the incidence of 5-fluorouracil-based chemotherapy-induced stomatitis. However, no reports have described the effects of IM when used for direct stomatitis. We therefore studied the development of an IM oral spray for stomatitis treatment and obtained evidence of direct effects.
