医療薬学
Online ISSN : 1882-1499
Print ISSN : 1346-342X
ISSN-L : 1346-342X
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CarboplatinはCisplatinへ変化する?
-各種水溶液中での経時変化-
藤本 亜弓加藤 隆児佐藤 卓史岡田 龍二吉開 晶一遠藤 幹子高橋 幸大今野 秀樹井尻 好雄三野 芳紀千熊 正彦田中 一彦林 哲也
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2018 年 44 巻 8 号 p. 417-421

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Although it was reported that carboplatin, a second-generation platinum agent, exhibits an anti-cancer effect after the structure is changed from carboplatin to cisplatin, how this change takes place remains unclear. In this study, the stability of carboplatin to pH and Cl- concentration was examined by HPLC using πNAP column. In the absence of sodium chloride, carboplatin did not change to cisplatin. However, in the presence of sodium chloride at pH 3.0 and 6.0, carboplatin changed to cisplatin after 8 hr and carboplatin changed to 0.33 mmol cisplatin at 24 hr in the presence of sodium chloride at pH 3.0. The result of this study shows that when carboplatin was mixed with an infusion solution of inorganic salts including chloride, the solution should be infused within 8 hr.

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