酸化マグネシウム錠の一包化によるセロハンポリエチレンラミネート包装内の湿度評価

抄録

Whether hygroscopic medicines can be stored in one-dose packages is often judged by information based on the quality evaluations of nonpackaged medicines. We previously reported that moisture absorption of nonpackaged hygroscopic medicines absorbed more moisture than did those stored in one-dose packages. In addition, when more than one of the same or different types of hygroscopic medicines were stored together in one-dose packages, the amount of moisture absorbed by each medicine is lower than that absorbed by medicine stored separately in one-dose packages. Moisture absorption of hygroscopic medicines usually depends on the humidity of the preservation environment. In this study, we measured the humidity change inside one-dose packages of cellophane polyethylene laminating paper included with magnesium oxide tablets, which are hygroscopic medicines, under 75％ relative humidity and 25℃. The humidity inside one-dose packages declined when magnesium oxide tablets were stored inside the packages. That effect was strongly dependent on the number of magnesium oxide tablets in the one-dose packages. Therefore, the moisture absorption of Glucobay^® and Glucobay^® OD tablets stored in one-dose packages was reduced when the tablets were stored with magnesium oxide tablets. This inhibitory effect also correlated with the quantity of magnesium oxide. In conclusion, the humidity inside one-dose packages containing hygroscopic medicines such as magnesium oxide tablets was lower than the humidity inside one-dose packages that did not contain hygroscopic medicines; thus, hygroscopic medicines may help preserve the quality of other hygroscopic medicines when packaged together inside one-dose packages.