がん化学療法における吃逆に対する柿蔕煎液の有効性

抄録

The clinical efficacy of shitei decoction for the treatment of hiccups in patients undergoing cancer chemotherapy was retrospectively investigated. The control group was treated with metoclopramide. The clinical efficacy was assessed based on complete remission (hiccups disappeared within 2 days of administration of shitei decoction or metoclopramide), remission (hiccups disappeared > 3 days after the administration of shitei decoction or metoclopramide), and no effect (hiccups did not disappear after the administration of shitei decoction or metoclopramide and required other drugs to be added to the shitei decoction or metoclopramide). Among the 85 patients treated with shitei decoction, 43 had complete remission, 35 had remission, and 7 had no effect. Conversely, among the 19 patients treated with metoclopramide, 5 had complete remission, 8 had remission, and 6 had no effect. Compared with metoclopramide, shitei decoction was found to be significantly more effective. Thus, these data suggest that shitei decoction is effective for the treatment of hiccups in patients undergoing cancer chemotherapy.