アブラキサン^®再溶解時間に対する側孔型プラスチック製注射針の有用性に関する検討

抄録

Albumin-bound paclitaxel (Abraxane^®) is a lyophilized preparation that takes time to dissolve. Previously, we used a metal needle for dissolving Abraxane^®. We then transitioned to a side hole-type plastic needle to prevent accidental needle-stick injuries. There is no literature regarding the ideal needle type, according to the material it is made of, for dissolving Abraxane^®, and the effect on the characteristics of Abraxane^® after dissolving with each needle is unknown. Therefore, we investigated the efficacy of the plastic needle for dissolving Abraxane^®. The formulation was dissolved in three ways: by injecting saline for 30 s with a metal needle (M30s), injecting saline for 15 s with a plastic needle (P15s), and injecting saline for 30 s with a plastic needle (P30s). Each group was kept at rest for 5 min after saline infusion, and then the dissolution time was estimated. The median dissolution time was 82.5 (15 - 210) s for M30s, 75 (30 - 135) s for P15s, and 45 (15 - 120) s for P30s. P30s had a significantly shorter dissolution time than M30s (P < 0.01) and P15s (P < 0.05). There was no significant difference in the dissolution time between M30s and P15s; however, P15s tended to have a shorter dissolution time than M30s. We measured the diameter of Abraxane^® particles after dissolving with each needle and found that the diameter was almost the same. Therefore, a side hole-type plastic needle might reduce the dissolution time compared with a metal needle without affecting the characteristics of Abraxane®.