人工膝関節全置換術周術期におけるデュロキセチン使用の有効性と安全性の評価

抄録

The purpose of this study was to compare the efficacy and safety of using duloxetine and tramadol acetaminophen for the pain of knee osteoarthritis during the perioperative period of total knee arthroplasty (TKA). For pain, the difference between resting and postoperative body movements was investigated based on the absolute value of the numerical evaluation scale (NRS) before and after surgery during rest and body movement and the NRS immediately after surgery (postoperative). In terms of efficacy, the absolute values of NRS were significantly lower in the duloxetine group than in the tramadol acetaminophen group, both at rest and during physical activity. On the other hand, when comparing the difference in NRS immediately after surgery and at some other timepoint after surgery, the duloxetine group and tramadol acetaminophen group were almost the same at any time after surgery. Adverse events occurred in the duloxetine group and tramadol acetaminophen group, which were almost the same as the frequently occurring adverse events in the package inserts. Since chronic postsurgical pain (CPSP), which causes a deterioration in quality of life for patients after TKA, interferes with daily life, it is important to perform appropriate pain management, and pain management with duloxetine may help.