病院薬学
Online ISSN : 2185-9477
Print ISSN : 0389-9098
ISSN-L : 0389-9098
桃核承気湯エキス顆粒剤と煎剤との比較
鳥居塚 和生本間 精一中川 輝昭木村 昌行上野 雅晴堀越 勇寺沢 捷年
著者情報
ジャーナル フリー

1984 年 10 巻 1 号 p. 29-34

詳細
抄録

Comparison between the original decoctions of “Toukakujohki-toh, ” one of the commonly prescribed formulas in oriental medicine, and the granules of the extracts of 6 commercially available brands was studied on the following subjects;1) Contents of cinnamic aldehyde, cinnamic acid and glycyrrhizic acid;2) TLC profiles of the freeze-dried decoction and of the granules extracted with n-hexane, chloroform and methanol;3) Effects on blood coagulation and fibrinolysis in vitro. In all of the six brands, the total amount of extracts in the daily dose was smaller than 1/3 of the original decoctions. Especially, volatile compounds in the granules such as cinnamic aldehyde and cinnamic acid were remarkably reduced as compared with those in the decoctions. The TLC profiles of 2 preparations, decoctions and granules also showed a difference from each other.
It was indicated that the effects of the granules of Toukakujohki-toh extracts on coagulation measured in prothromdin time and activated partial thromboplastin time and on fibrinolysis of urokinase measured by fibrin plate method were only 10% of the effects of original decoctions.

著者関連情報
© 一般社団法人 日本医療薬学会
前の記事 次の記事
feedback
Top