抄録
Treatment of triethylene tetramine with anhydrous methanolic hydrogen chloride solution derived from acetyl chloride and methanol at 0°C, followed by recrystallization provided pure triethylene tetramine dihydrochloride (trien) which turned out to be less hygroscopy than that prepared by the preceeding procedure. Examination of its stability and drug activity under various conditions suggests that an aqueous solution of trien could also be useful for the treatment of Wilson's disease.
