病院薬学
Online ISSN : 2185-9477
Print ISSN : 0389-9098
ISSN-L : 0389-9098
無菌製剤処理化高力ロリー輸液剤でのビタミンの長期安定性に関する薬剤学的研究
八野 芳巳山崎 邦夫岩重 秀二新田 剛古川 佳也
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ジャーナル フリー

1988 年 14 巻 5 号 p. 370-373

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For the purpose of supply of intravenous hyperalimentation solutions (IVH) for home care, we examined long-term stability, especially vitamins B1, B2, C and A for two weeks to monitor changes in hospital coded prescription, IVH 1-5.
Decrease of vitamin B1 was observed in IVH 1-4 with time.It was decreased by 27.0-40.5 % on the 14th day, while in IVH 5 the concentration decreased to at 83.7%.Vitamine C showed the next largest decrease to 65.1% being retained two weeks in IVH 5.In IVH 1-4, on the other hand, it remained at 83.6-94.4%.Other two vitamins B2 and A remained stable at the comparatively high level of 80.9-101.4% in each preparation.
From the results, it is seemed that if the constituents of IVH are given sufficient consideration, it would be possible to guarantee the long-term stability of IVH with vitamins in the index of vitamins B1 and C.
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