Abstract
The mechanism of diazepam loss into the administration set was investigated in equilibrium and kinetic studies.A linear relation was found between the absorbed amount of diazepam by the administration set and the equilibrium concentration within the range of 4.0-20.0μg/ml at 30°C.
This result suggests that diazepam loss into the administration set occurs through a mechanism of partition and diffusion similarly to isosorbide dinitrate or nitroglycerin.When the diazepam solution was passed through the administration set at a flow rate of 1.08ml/min, initial concentration 50μg/ml and the length of administration set 100cm, the diazepam concentration was reduced to 62.6% in 10 min, and gradually returned to the initial level with time.it was found that the factors effecting the loss of diazepam were the kind of containers, the length of administration set and the flow rate of intravenous solutions.
