抄録
The automatic dispensing system which is connected between the prescription ordering system and automatic tablet counting and packing system (ATC) machine has been developed in recent years. The quality control of tablets and capsules (unsealed) in ATC and the stability of these drugs after ATC package must be considered for packing these drugs in a one dose-package by automatic dispensing system. Therefore, we selected 190 drugs (tablets and capsules) from the drugs adopted in our hospital and stored in a light-resistant or moistureproof place as mentioned in package inserts, and investigated the stability of these tablets and capsules (unsealed condition) with time when they were stored in the ATC tablet cases provided in our dispensary and under the conditions of constant temperature and humidity (in a dark place, at 20°C and 52%RH). In our study, we used a new tablet case devised for improving the light-resistant and maintained appropriate conditions of temperature and humidity in the dispensary by using an air conditioning system continuously. As a result, the quality control of these drugs stored in ATC was greatly improved. The appearance of ASPARA K®, DEPAKENE ®and AUGMENTIN ® were changed markedly under the sealed condition in ATC by temperature and humidity. We judged from our findings that the application of these three drugs to the automatic dispensing system is by far difficult since there are still problems to be solved for the quality control of these drugs.
