抄録
The pharmacokinetics of phenobarbital (PB) was studied in 12 newborn infants following an acute i. v. and rectal administrations, respectively. In the 10 newborns whose gestational ages were 34 to 42 weeks and 2 infants whose ages were 6 and 13 months. The subjects were seizure or intraventricular hemorrhage or asphyxia at birth. PB pharmacokinetics was compared with single dose administration. The corresponding t1/ 2 for the i. v. dose was 103.4±65.5 hr (m±S. D.) and 138.06±100.1 hr (m±S. D.) after rectal administration. Maximum concentrations 10.25±3.4 μg/ ml (4.07-14.19 μg/ml) were reached between 5.68 and 30.13 hr after rectal administration. This variation in acute PB disposition for newborns is probably of limited clinical importance.
