市販注射剤の物理的性状と溶血性との関係および溶血性の減弱化について

抄録

Hemolytic property of the solutions of various pH values and osmotic pressures were studied. Of these solutions and 280 commercial injections studied, those of pH under or above the range of 4.5-11.0 or the osmotic pressures under or above 0.5-5.0 generally showed hemolytic property. Hemolytic action of most of the commercial injections having low osmotic pressures was reduced or disappeared, when sodium chloride was added to the injections to prepare isotonic solutions. The same phenomenon was generally observed when the injections having the hemolytic effect were mixed with 0.5-3.0ml of isotonic sodium chloride solution or with other injections. From these results, manufacture of safe commercial injections by the adjustment of osmotic pressure or the modification of dosage strength was required. Further, data for safe administration of intramuscular injections were obtained.