Particulate Matter Analyses after Dissolution of Powder Antibiotic Injections Used in the Pediatric Ward

抄録

Final filters have not been always used for injections in the pediatric ward of our hospital. Since thore has been no report on the particulate matters of five dissolved antibiotics in vial, we measured those amounts using a particle counter. The amounts of particulate matters in the solutions of cefpirome sulfate, flomoxef sodium and panipenem/betamipron were below the limits defined by the Japanese Pharmacopoeial Forum (1996) or United States Pharmacopoeia (USP XXIII). However, particles above 10μm in imipenem/cilastatin sodium and vancomycin hydrochloride immediately after dissolution were about 70% of the limit. Scanning electron micrographs of the filter membrane surface showed the existence of insoluble particulate contaminants in those injections. Final filters are recommended for these antibiotic injections to be used safely in pediatric patients.