抄録
A comparison was made between a mixed preparation of Pandel® corticosteroid ointment with zinc oxide ointment (hereafter referred to as “Pan: Z” ) and a mixed preparation of Pandel® corticosteroid ointment with Urepal® urea ointment ( “Pan: U” ), regarding the therapeutic effect and safety, moisturizing effect, the feel of the ointment, and usefulness as an overall evaluation, in 6 patients with atopic dermatitis (AD).
With regard to the therapeutic effect, although differences were observed between the mixed ointments in some cases for certain periods, ultimately the degree of improvement in the symptoms was approximately the same for all cases. The reason for this is considered to be the presence of corticosteroid ointment as the central therapy in both mixed ointments. No side effects were caused by either of the mixed ointments.
With regard to the moisturizing effect, Pan: U was found to be superior to Pan Z. This is considered to be mainly due to the difference between zinc oxide ointment and Urepal®, with Urepal® which has a direct moisture-restoration effect on dry skin in AD.
Regarding the feel of the ointment as well, Pan: U was considered to be superior to Pan: Z. This difference is considered to reflect the moist feeling of Urepal®.
As a result, Pan: U was evaluated to be superior to Pan: Z in terms of usefulness.
Prior to the clinical study on AD patients, the moisturizing effect of 5 ointments was examined in subjects with healthy skin. As a result, the ointments were divided broadly into 2 categories including emollients and moisturizers in line with the mechanism of the moisturizing effect according to the properties of the base.
The moisturizing effect of the ointments themselves was significant, ranking in the following order: Urepal®>Hirudoido®> Sahne® zinc oxide ointment > Keratinarnin®.
Pan: Z and Pan: U are selected for use according to the skin symptoms. When the moisturizing effect and feeling of use are also taken into account, however, Pan: U is considered to be superior to Pan: Z. Among the 5 ointments, Urepal® and Hirudoid® are also considered to have a particularly good moisturizing effect.
